Dr. Syed presents pathological events leading up to the type 1 diabetes mellitus (T1DM). Topics covered are:
+T1DM is an autoimmune disease.
+Role of genetic mutations and allele inheritance for DQ, DR3 and DR4 in the HLA region on chromosome 6p21.
+Role of polymorphism in insulin, CTLA4, and other molecules.
+Role of incorrect T cell training in Thymus.
+Role of cytotoxic T cells in beta cell damage. Leading to insulitis.
+Role of humoral/antibody response causing beta cell damage. Leading to insulitis.
+Incorrect formation of MHC molecules increasing affinity for the self-antigens.
+Other autoimmune diseases that may be present with T1DM.
Learning objectives of this video are the following:
1. Definition of diabetes mellitus type-1.
2. Epidemiology.
3. Concept of normal immune mechanisms for combating an antigen.
4. Abnormalities in these mechanisms.
5. How autoimmune diseases occur?
6. Application of above mentioned concepts to explain pathophysiology diabetes mellitus type-1.
Presented by Dr. Mobeen Syed
No credit card information needed.
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2 Comments
joseph.p.reo@*.com
Oct 18 2018, 9:49 am
I don’t have access even though I have a lifetime access membership. Please rectify. Thanks.
anmol.agrawal85.aa@*.com
Oct 07 2018, 12:30 pm
I HAVE A LIFE TIME ASSESS STILL NOT ABLE TO OPEN THIS VIDEO. WHYYYYYYYY???